ISIS PHARMACEUTICALS INC

CUSIP: 46433010 Class: COM

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP's Holding History (CIK: 0001164508)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 387,915 Value ($000) $22,325 Avg Close — Range —
Q2 2015
Shares 387,915 Value ($000) $22,325 Avg Close — Range —
Q3 2013
Shares 155,564 Value ($000) $5,840 Avg Close — Range —